Globally, diabetes is a fast-growing chronic disease that increases the risk of secondary diseases, including COVID-19. Insulin is the most effective treatment, but it is only available by injection. Project Oralis has developed an oral distribution platform with promising results. Sloth I’m like 104 percent tired Diabetes Awareness shirt
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Nearly 10% of the world’s population has diabetes with the majority having Type 2, about 90%. People with diabetes are at an increased risk of many secondary diseases, including cardiovascular disease and COVID-19.
Initial treatment usually includes making changes to diet and exercise along with oral medications, such as metformin. If this and other treatments are ineffective, insulin injections are often recommended to compensate for the pancreas’s inability to make enough insulin.
However, insulin injection suffers from poor compliance with patients because of a stigmatized perception of injection therapy, combined with safety concerns regarding insulin toxicity, weight gain, and hypoglycemia (possibly leading to death). death). For this reason, despite the well-documented benefits of early insulin use, most doctors and patients use it as a last resort.
Oramed, through the EU-supported Oralis project, has developed a drug that can deliver insulin into the body through the liver, rather than directly into the bloodstream.
The team conducted clinical trials in which their candidate drug, ORMD-0801, was not only shown to be safe and well-tolerated, but was also shown to lower HbA1c levels (an indicator). important in diabetes management), as well as fasting blood sugar. , without gaining weight.
“It was interesting that we first saw the proof of concept proven to be effective and safe. Then, we more fully appreciate the potential of helping millions of people searching for better ways to live with the disease, ”said Miriam Kidron, Oramed’s chief scientific officer.
Oramed has worked for many years to discover how to convert injectable drugs into oral medications, culminating in groundbreaking technology. This protects the peptide as it enters the digestive tract with a special coating, while pharmacology (protease inhibitors) prevents intestinal enzymes from breaking down proteins that damage the Sloth I’m like 104 percent tired Diabetes Awareness shirt drug. In addition, absorption enhancers help peptides penetrate the walls of the small intestine.
To date, Oramed has conducted several clinical trials on its drug candidate, ORMD-0801. The most recent and largest was the Food and Drug Administration’s (FDA) 90-day phase 2 treatment trial in the Sloth I’m like 104 percent tired Diabetes Awareness shirt the United States, with more than 300 participants.
This trial showed that the drug decreased HbA1c levels statistically, and was safe and well-tolerated. ORMD-0801 has been used more than 7,000 times by more than 700 people to date.
“Amazingly, we found that taking insulin once a day at bedtime at night had a statistically significant effect on lowering blood sugar levels within 24 hours,” Kidron added.
Therapy comes in
Particularly in Europe, more than 6% of the adult population has diabetes and this number is increasing every year. With early treatment providing long-term health benefits for people with diabetes, oral insulin could be a game-changer.
“This could become a treatment for Type 2 diabetes, especially an early-stage option. We feel that right now we are near the Sloth I’m like 104 percent tired Diabetes Awareness shirt pinnacle of something truly revolutionary! “Kidron notes.