Taking advantage of the cancer cell’s altered metabolism to promote its rapid growth, Princess Margaret researchers are studying these molecular changes to help them develop drug targets. more precisely for one of the deadliest breast cancers. Wine Glasses Butterflies Breast cancer shirt, sweater.
Triple-negative breast cancer is a very powerful secondary breast cancer, accounting for 15-20% of all breast cancer cases, but 25% of all breast cancer deaths. Additionally, it has a higher rate of metastasis within five years of being diagnosed and a lower overall survival rate than receptor-positive cancers.
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The disease does not have an exact drug, so the patient is treated with chemotherapy because we don’t have a definite treatment goal. Initially, it worked for some patients, but nearly a quarter of them relapsed within 5 years of being diagnosed, and many developed chemotherapy-resistant tumors.
These barbaric statistics mean we have to advance our understanding of the molecular basis for this cancer’s growth in order to find effective, precise targets for drugs and a companion trial to determine which patients are most likely to benefit from such therapy. ”
Dr. Mathieu Lupien, Senior Scientist, Princess Margaret Cancer Center
In the research conducted by Princess Margaret Senior Scientists. Cheryl Arrowsmith and Mathieu Lupien published in Nature Communications, August 21, 2020, the team found a promising approach to a protein biomarker capable of identifying the best patients. for more precise targeted therapy in the future.
Using a collection of different patient-derived cell lines from tricyclic breast cancer, researchers can test their sensitivity to a ‘chemical probe’ (compound test, like drugs) against a metabolic gatekeeper inhibitor called GLUT1. They found a correlation or binding between cells with different levels of RB1, a protein involved in cell metabolism, as well as a long-standing tumor suppressor protein and reducing growth of these cancer cells.
The altered metabolism promotes cancer exploding
All cancers experience changes in metabolic state, because their explosive growth requires large amounts of energy, such as glucose, to nurture survival, Dr. Arrowsmith explains. and their development – despite being affected by chemotherapy in this particular cancer.
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Access to diverse cell models of tri-negative breast cancer allows us to differentiate between which drugs are potentially effective and those that won’t work, Tien said Dr. Lupien, who is also an Associate Professor at the Department of Medical Physiology. “Without the broad spectrum of these samples, we would have missed this subset of the three-reactive negative breast cancers with our compound.”
Specifically, this compound targets GLUT1, part of the Wine Glasses Butterflies Breast cancer shirt, sweater glucose transport pathway into cells to increase metabolic energy in a group of cancer cells high in the RB1 protein – to stop them from growing.
Blocking this pathway “starves” cancer cells, making them more reactive or sensitive to chemical compounds, proving promising targets for new anticancer approaches.
This work shows that different levels of RB1 can be used as a biomarker to differentiate between those who respond to treatment and those who do not respond in the Wine Glasses Butterflies Breast cancer shirt, sweater future, Dr. Arrowsmith said.