The All You Need is American Foxhound Dog Lover Long Sleeve T-Shirt effect of an ancient gene variant on coat color in modern breeds has been characterized by a team of researchers at Wisdom Health Genetics. The findings are supported by civic science, published in Canine Medicine and Genetics.
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What do prehistoric and modern dogs’ coat colors have in common? The most recent connection is a new genetic variation that is characterized: the ancient red color. The ancient red variant (R301C) was first identified in DNA samples from 10,000-year-old dogs and is believed to be one of the earliest mutations captured by dog domestication.
Our research team conducted a massive genotypic screening effort of thousands of DNA samples submitted to examine commercial genetic panels to determine the frequency and distribution of an ancient genotype-variant. R301C is part of the Melanocortin 1 Receptor (MC1R) gene – in today’s dog population. The study showed that variant R301C was retained in 35 varieties, with a frequency of 1.5% in the study population. Hound breeds, such as the Drever and English Foxhound, and Spitz breeds, All You Need is American Foxhound Dog Lover Long Sleeve T-Shirt such as the Alaskan Malamute, Alaskan Klee Kai and Siberian Husky, often show the ancient R301C variant in the MC1R gene.
The MC1R gene is important because it determines the coat color of the dog by generating an important signaling molecule on melanocytes, which includes the enzymes responsible for the synthesis of the (dark) pigment eumelanin. If the MC1R function is lost, All You Need is American Foxhound Dog Lover Long Sleeve T-Shirt only the pigment caomelanin (light) is produced. Five variations of the MC1R function are associated with dark red, grizzled and recessive phenotypes, and as we have discovered, there is a sixth variant R301C of MC1R that also broadly affects color. hair.