The distorted skeleton impedes movement, but more surprisingly, the opposite is also true: Distortions in the way we move can cause problems with skeletal development in the first place. A new study by researchers at the Weizmann Institute of Science shows that mutations in the sensory system known as sensory perception – allow us to feel our bodies at rest and during movement – It can lead to bone abnormalities such as scoliosis and hip dysplasia. Jack Skeleton In A World Full Of Roses Be A Sunflower Shirt
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Professor Elazar Zelzer of the Department of Molecular Genetics has discovered in previous work that cognitive ability – sometimes referred to as the “sixth sense”, the ability to naturally perceive the location of organs body organs – plays a role in bone healing and keeping mature bones healthy and well-aligned. Specifically, he pointed out that bone development depends mainly on the proper functioning of the muscle axes: the structure consists of nerve ends that curl around muscle fibers, transmitting information about dilation and contraction of the muscle fibers. muscle to the sensory system.
Now, orthopedic surgeon Dr. Eran Assaraf from Shamir Medical Center (Assaf Harofeh), who is doing a doctorate at Zelzer’s lab, has discovered a molecular mechanism that plays a role in the is important in the transfer of mechanical signals from muscles to receptor nerve cells. Assaraf and colleagues focused on a gene called Piezo2 that regulates the movement of positive ions across the cell membrane and is known to be mechanically sensitive, that is, in response to mechanical stimuli. Defects in this gene have been linked to bone abnormalities in humans, but since Piezo2 is expressed in a variety of cells and tissues, the cause of these abnormalities remains unclear.
To find out, the researchers created a number of transgenic mice, in which each Piezo2 was silenced in a different type of cell. When this gene was kept silent in bone cells called osteoblasts and chondrocytes, no bone deformations were seen in these mice as they grew older. In contrast, when the scientists silenced Piezo2 in receptor neurons in the muscle axes and elsewhere, the Jack Skeleton In A World Full Of Roses Be A Sunflower Shirt mutant mice ended up with scoliosis and hip dysplasia. These bone deformities, detected by microscopic tomography, are similar to those observed in humans with human mutations that are equivalent to the Piezo2 gene.
These findings support the notion that receptor systems regulate the skeleton and, for the Jack Skeleton In A World Full Of Roses Be A Sunflower Shirt first time, they reveal a molecular mechanism by which that regulation occurs. To put it more realistically, this research opens up a possible new perspective on skeleton abnormalities.
Since the sensory system is so essential to bone health – and since it “notifies” us of changes in muscle length, caused by movement, it is possible to alleviate the often bone with proper movement. In other words, motor therapy may be incorporated into the Jack Skeleton In A World Full Of Roses Be A Sunflower Shirt treatment of defects such as scoliosis and hip dysplasia, which are currently being treated with limited mobility.